Reversible Inactivation and Excitation of Nucleus Raphe Magnus Can Modulate Tail Blood Flow of Male Wistar Rats in Response to Hypothermia

نویسندگان

  • Abdorahman Sarihi
  • Alireza Komaki
  • Behnam Heshmatian
  • Gila Behzadi
  • Masoomeh Kourosh Arami
  • Mehrangiz Vahabian
  • Siamak Shahidi
  • Sohrab Hajizadeh
چکیده مقاله:

Background: The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. Introduction: we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. Methods: Hypothermia was induced in Male Wistar rats and cannula was implanted above the NRM. To evaluate the effect of nucleus inactivation on TBF, the amount of TBF was measured by Laser Doppler in hypothermic rats, before and after lidocaine microinjection into NRM. TBF was also measured after glutamate microinjection to assess the effect of nucleus excitation in hypothermic rats. Results: Results indicated that after dropping TBF by hypothermia, microinjection of lidocaine into NRM significantly decreased TBF from 54.43 ± 5.7 to 46.81 ± 3.4, whereas glutamate microinjection caused a significant increase from 44.194 ± 0.6 to 98 ± 10.0. Conclusion: These data suggest that NRM have thermoregulatory effect in response to hypothermia.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male wistar rats in response to hypothermia

background: the nucleus raphe magnus (nrm) is involved in thermoregulatory processing. there is a correlation between changes in the firing rates of the cells in the nrm and the application of the peripheral thermal stimulus. introduction: we examined the effect of reversible inactivation and excitation of nrm on mechanisms involved in tail blood flow (tbf) regulation in hypothermia. methods: h...

متن کامل

Reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male Wistar rats in response to hypothermia.

BACKGROUND The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. INTRODUCTION we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. METHODS ...

متن کامل

Nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia

Objective(s): Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. Materials and Methods: To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of ...

متن کامل

nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia

objective(s): nucleus raphe magnus (nrm) that is involved in the regulation of body temperature contains nitric oxide (no) synthase. considering the effect of no on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. materials and methods: to this end, tail blood flow of male wistar rats was measured by laser doppler following the induction of ...

متن کامل

Nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia

OBJECTIVES Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. MATERIALS AND METHODS To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of hy...

متن کامل

The Effects of Lidocaine Reversible Inactivation of the Dorsal Raphe Nucleus on Passive Avoidance Learning in Rats

Introduction: The role of serotonergic fibers in avoidance learning is controversial. Involvement of the dorsal raphe nucleus (DRN), the main source of hippocampal projecting serotonergic fibers in acquisition, consolidation and retrieval of passive avoidance (PA) learning, was investigated by functional suppression of this area. Materials and Methods: DRN functional inactivation was done by li...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 12  شماره 4

صفحات  237- 240

تاریخ انتشار 2008-10

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023